ECCN 1C350

CBCWAT

Chemicals that may be used as precursors for toxic chemical agents .

Category: 1 - MaterialsProduct Group: C - MaterialsLast Updated: 2026-04-10

What This ECCN Covers

ECCN 1C350 controls chemicals that may be used as precursors for toxic chemical agents — essentially the building blocks of chemical weapons. The entry is organized by Chemical Weapons Convention (CWC) schedules: Schedule 1 (chemicals with few or no uses outside weapons), Schedule 2 (chemicals with limited commercial uses that could be diverted), and Schedule 3 (chemicals widely used commercially but still potential precursors). Controls serve both the Australia Group multilateral regime and U.S. CWC implementation obligations.

Who needs to check this?

Chemical manufacturers, specialty chemical distributors, pharmaceutical companies (some precursors overlap with pharma intermediates), and research institutions working with controlled chemicals.

Compliance tip

The Commerce Country Chart does NOT fully determine licensing for CW-controlled items. Schedule 2 chemicals require a license for export to States not Party to the CWC. Schedule 3 chemicals to non-States Parties require either a license or an End-Use Certificate from the importing government. Always check Supplement No. 2 to Part 745 for the CWC States Party list.

Reviewed by Jack Tan · Last reviewed: May 8, 2026

Items Covered

  • a.Chemicals Not Eligible
  • b.CWC Schedule 2 chemicals (States not Party to the CWC). No CWC Schedule 2 chemical or mixture identified in 1C350.b is eligible for sample shipment to States not Party to the CWC (destinations not listed in Supplement No. 2 to part 745 of the EAR) without a license.
  • b.Countries Not Eligible: Countries in Country Group E:1 of Supplement No. 1 to part 740 of the EAR are not eligible to receive sample shipments of any chemicals controlled by this ECCN without a license.
  • c.Sample shipments that require an End-Use Certificate for CW reasons: No CWC Schedule 3 chemical or mixture identified in 1C350.c is eligible for sample shipment to States not Party to the CWC (destinations not listed in Supplement No. 2 to part 745 of the EAR) without a license, unless an End-Use Certificate issued by the government of the importing country is obtained by the exporter prior to export (
  • d.Sample shipments that require a license for reasons set forth elsewhere in the EAR: Sample shipments, as described in this Note 1, may require a license for reasons set forth elsewhere in the EAR. See, in particular, the end-use/end-user restrictions in part 744 of the EAR, and the restrictions that apply to embargoed countries in part 746 of the EAR.
  • e.Annual report requirement. The exporter is required to submit an annual written report for shipments of samples made under this Note 1. The report must be on company letterhead stationery (titled "Report of Sample Shipments of Chemical Precursors" at the top of the first page) and identify the chemical(s), Chemical Abstract Service Registry (C.A.S.) number(s), quantity(ies), the ultimate consignee's name and address, and the date of export for all sample shipments that were made during the previous calendar year. The report must be submitted no later than February 28 of the year following the calendar year in which the sample shipments were made, to: U.S. Department of Commerce, Bureau of Industry and Security, 14th Street and Pennsylvania Ave. NW, Room 2099B, Washington, DC 20230, Attn: "Report of Sample Shipments of Chemical Precursors."
  • a.Mixtures that contain precursor chemicals identified in ECCN 1C350, in concentrations that are below the levels indicated in 1C350.b through .d, are controlled by ECCN 1C395 or 1C995 and are subject to the licensing requirements specified in those ECCNs.
  • b.A license is not required under this ECCN for a mixture, when the controlled chemical in the mixture is a normal ingredient in consumer goods packaged for retail sale for personal use. Such consumer goods are designated EAR99. However, a license may be required for reasons set forth elsewhere in the EAR.
  • Exclusion. No chemical may be added to the mixture (solution) for the sole purpose of circumventing the Export Administration Regulations;
  • b.Percent Weight Calculation. When calculating the percentage, by weight, of ingredients in a chemical mixture, include all ingredients of the mixture, including those that act as solvents.
  • b.Australia Group-controlled precursor chemicals also identified as Schedule 2 chemicals under the CWC, as follows, and mixtures in which at least one of the following chemicals constitutes 30 percent or more of the weight of the mixture:
  • 1. (C.A.S. #7784-34-1) Arsenic trichloride;
  • 2. (C.A.S. #76-93-7) Benzilic acid;
  • 3. (C.A.S. #78-38-6) Diethyl ethylphosphonate;
  • 4. (C.A.S. #683-08-9) Diethyl methylphosphonate;
  • 5. (C.A.S. #15715-41-0) Diethyl methylphosphonite;
  • 6. (C.A.S. #2404-03-7) Diethyl-N,N-dimethylphosphoroamidate;
  • 7. (C.A.S. #41480-75-5) N,N-Diisopropylaminoethanethiol hydrochloride;
  • 8. (C.A.S. #5842-07-9) N,N-Diisopropyl-beta-aminoethane thiol;
  • 9. (C.A.S. #96-80-0) N,N-Diisopropyl-beta-aminoethanol;
  • 10. (C.A.S. #96-79-7), N,N-Diisopropyl-beta-aminoethyl chloride;
  • 11. (C.A.S. #4261-68-1) N,N-Diisopropyl-beta-aminoethyl chloride hydrochloride;
  • 12. (C.A.S. #6163-75-3) Dimethyl ethylphosphonate;
  • 13. (C.A.S. #756-79-6) Dimethyl methylphosphonate;
  • 14. (C.A.S. #677-43-0) N,N-dimethylamino-phosphoryl dichloride;
  • 15. (C.A.S. #1498-40-4) Ethyl phosphonous dichloride [Ethyl phosphinyl dichloride];
  • 16. (C.A.S. #430-78-4) Ethyl phosphonus difluoride [Ethyl phosphinyl difluoride];
  • 17. (C.A.S. #1066-50-8) Ethyl phosphonyl dichloride;
  • 18. (C.A.S. #993-13-5) Methylphosphonic acid;
  • 19. (C.A.S. #676-98-2) Methylphosphonothioic dichloride.
  • 20. (C.A.S. #464-07-3) Pinacolyl alcohol;
  • 21. (C.A.S. #1619-34-7) 3-Quinuclidinol;
  • 22. (C.A.S. #111-48-8) Thiodiglycol.
  • c.Australia Group-controlled precursor chemicals also identified as Schedule 3 chemicals under the CWC, as follows, and mixtures in which at least one of the following chemicals constitutes 30 percent or more of the weight of the mixture:
  • 1. (C.A.S. #762-04-9) Diethyl phosphite;
  • 2. (C.A.S. #868-85-9) Dimethyl phosphite (dimethyl hydrogen phosphite);
  • 3. (C.A.S. #139-87-7) Ethyldiethanolamine;
  • 4. (C.A.S. #10025-87-3) Phosphorus oxychloride;
  • 5. (C.A.S. #10026-13-8) Phosphorus pentachloride;
  • 6. (C.A.S. #7719-12-2) Phosphorus trichloride;
  • 7. (C.A.S. #10545-99-0) Sulfur dichloride;
  • 8. (C.A.S. #10025-67-9) Sulfur monochloride;
  • 9. (C.A.S. #7719-09-7) Thionyl chloride;
  • 10. (C.A.S. #102-71-6) Triethanolamine;
  • 11. (C.A.S. #122-52-1) Triethyl phosphite;
  • 12. (C.A.S. #121-45-9) Trimethyl phosphite.
  • d.Other Australia Group-controlled precursor chemicals not also identified as Schedule 1, 2, or 3 chemicals under the CWC, as follows, and mixtures in which at least one of the following chemicals constitutes 30 percent or more of the weight of the mixture:
  • 1. (C.A.S. #1341-49-7) Ammonium hydrogen fluoride;
  • 2. (C.A.S. #107-07-3) 2-Chloroethanol;
  • 3. (C.A.S. #109-89-7) Diethylamine;
  • 4. (C.A.S. #100-37-8) N,N-Diethylaminoethanol;
  • 5. (C.A.S. #589-57-1) Diethyl chlorophosphite;
  • 6. (C.A.S. #298-06-6) O,O-Diethyl phosphorodithioate;
  • 7. (C.A.S. #2465-65-8) O,O-Diethyl phosphorothioate;
  • 8. (C.A.S. #108-18-9) Di-isopropylamine;
  • 9. (C.A.S. #124-40-3) Dimethylamine;
  • 10. (C.A.S. #506-59-2) Dimethylamine hydrochloride;
  • 11. (C.A.S. #142-84-7) Dipropylamine
  • 12. (C.A.S. #762-77-6) Ethyl chlorofluorophosphate;
  • 13. (C.A.S. #1498-51-7) Ethyl dichlorophosphate;
  • 14. (C.A.S. #460-52-6) Ethyl difluorophosphate;
  • 15. (C.A.S. #7664-39-3) Hydrogen fluoride;
  • 16. (C.A.S. #3554-74-3) 3-Hydroxyl-1-methylpiperidine;
  • 17. (C.A.S. #76-89-1) Methyl benzilate;
  • 18. (C.A.S. #754-01-8) Methyl chlorofluorophosphate;
  • 19. (C.A.S. #677-24-7) Methyl dichlorophosphate;
  • 20. (C.A.S. #22382-13-4) Methyl difluorophosphate;
  • 21. (C.A.S. #14277-06-6) N,N Diethylacetamidine;
  • 22. (C.A.S. #53510-30-8) N,N-Diethylbutanamidine;
  • 23. (C.A.S. #90324-67-7) N,N-Diethylformamidine;
  • 24. (C.A.S. #1342789-47-2) N,N Diethylisobutanamidine;
  • 25. (C.A.S. #84764-73-8) N,N-Diethylpropanamidine;
  • 26. (C.A.S. #1315467-17-4) N,N-Diisopropylbutanamidine;
  • 27. (C.A.S. #857522-08-8) N,N-Diisopropylformamidine;
  • 28. (C.A.S. #2909-14-0) N,N-Dimethylacetamidine;
  • 29. (C.A.S. #1340437-35-5) N,N-Dimethylbutanamidine;
  • 30. (C.A.S. #44205-42-7) N,N-Dimethylformamidine;
  • 31. (C.A.S. #321881-25-8) N,N-Dimethylisobutanamidine;
  • 32. (C.A.S. #56776-14-8) N,N-Dimethylpropanamidine;
  • 33. (C.A.S. #1339586-99-0) N,N-Dipropylacetamidine;
  • 34. C.A.S. #1342422-35-8) N,N-Dipropylbutanamidine;
  • 35. (C.A.S. #48044-20-8) N,N-Dipropylformamidine;
  • 36. (C.A.S. #1342700-45-1) N,N-Dipropylisobutanamidine;
  • 37. (C.A.S. #1341496-89-6) N,N-Dipropylpropanamidine;
  • 38. (C.A.S. #1314-80-3) Phosphorus pentasulfide;
  • 39. (C.A.S. #75-97-8) Pinacolone;
  • 40. (C.A.S. #7789-29-9) Potassium bifluoride;
  • 41. (C.A.S. #151-50-8) Potassium cyanide;
  • 42. (C.A.S. #7789-23-3) Potassium fluoride;
  • 43. (C.A.S. #3731-38-2) 3-Quinuclidone;
  • 44. (C.A.S. #1333-83-1) Sodium bifluoride;
  • 45. (C.A.S. #143-33-9) Sodium cyanide;
  • 46. (C.A.S. #7681-49-4) Sodium fluoride;
  • 47. (C.A.S. #16893-85-9) Sodium hexafluorosilicate;
  • 48. (C.A.S. #1313-82-2) Sodium sulfide;
  • 49. (C.A.S. #637-39-8) Triethanolamine hydrochloride;
  • 50. (C.A.S. #116-17-6) Tri-isopropyl phosphite.

2 items reserved by BIS (not shown)

Control Reasons

CBChemical & Biological Weapons

Items controlled for chemical and biological weapons proliferation concerns.

Column 1: YesColumn 2: No
CWChemical Weapons Convention

Items controlled pursuant to the Chemical Weapons Convention (CWC) implementation.

Column 1: YesColumn 2: No
ATAnti-Terrorism

Items controlled for anti-terrorism reasons. Most items on the CCL have AT controls.

Column 1: YesColumn 2: No

Disclaimer

This information is for reference only. For official classifications, consult BIS or a qualified export control professional.

Official Reference

View on BIS Website

Related ECCNs

1C3951C995

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